AIxBio Resources

Essential Reading

Start here for an introduction to AIxBiosecurity:

1. Understanding AI-Facilitated Biological Weapon Development - Centre for Long-Term Resilience
   Overview of how AI capabilities intersect with biological risks

2. The Convergence of Artificial Intelligence and the Life Sciences - Nuclear Threat Initiative
   Foundational paper on AI-bio convergence and dual-use challenges

3. The near-term impact of AI on biological misuse - Centre for Long-Term Resilience
   Assessment of current and emerging risks from AI-enabled biology

4. Capability-Based Risk Assessment for AI-Enabled Biological Tools - Centre for Long-Term Resilience
   Framework for evaluating risks from AI biological design tools

5. Developing Guardrails for AI Biodesign Tools - Nuclear Threat Initiative
   Practical approaches to responsible development and deployment

Risk Assessments & Evaluations

Frameworks and methodologies for assessing AI-bio risks:

• Global Risk Index for AI-enabled Biological Tools - Centre for Long-Term Resilience & RAND Corporation

• Why we recommend risk assessments over evaluations for AI-enabled biological tools - Centre for Long-Term Resilience

• Virology Capability Test (VCT) - SecureBio evaluation and paper

• Assessing the Impacts of Technology Maturity and Diffusion on Malicious Biological Agent Development Capabilities - RAND Corporation

• Do the biorisk evaluations of AI labs actually measure the risk of developing bioweapons? - Epoch AI

• Toward Comprehensive Benchmarking of the Biological Knowledge of Frontier Large Language Models - RAND Corporation
  

Policy & Governance

Key policy documents and recommendations:

• Biosecurity Governance Across Uncertain Artificial Intelligence Futures - RAND Corporation

• How the UK Government should address the misuse risk from AI-enabled biological tools - Centre for Long-Term Resilience

• Biological Tools and the EU AI Act - Centre for Long-Term Resilience

• America’s AI Action Plan - U.S. Government

Technical Resources

Deep dives into capabilities and methods:

• The Age of AI in the Life Sciences

• Evaluating Safety and Security in Biological Research - RAND Corporation

• SecureBio AI x Biosecurity Resources - Comprehensive resource hub

• Issue Brief: Preliminary Taxonomy of AI-Bio Safety Evaluations - Frontier Model Forum

• Secure Bio Blog - Regular updates on AI biosecurity research

Research Agendas

Strategic priorities for the field:

• NTI AI-Bio Research Agenda - Nuclear Threat Initiative
  Key research questions and priorities for the AI biosecurity community